Tannic Acid Inhibits Protein Disulfide Isomerase, Platelet Activation and Thrombus Formation
نویسندگان
چکیده
منابع مشابه
Chlorogenic Acid Inhibits Human Platelet Activation and Thrombus Formation
BACKGROUND Chlorogenic acid is a potent phenolic antioxidant. However, its effect on platelet aggregation, a critical factor in arterial thrombosis, remains unclear. Consequently, chlorogenic acid-action mechanisms in preventing platelet activation and thrombus formation were examined. METHODS AND RESULTS Chlorogenic acid in a dose-dependent manner (0.1 to 1 mmol/L) inhibited platelet secreti...
متن کاملEndothelium-derived but not platelet-derived protein disulfide isomerase is required for thrombus formation in vivo.
Protein disulfide isomerase (PDI) catalyzes the oxidation reduction and isomerization of disulfide bonds. We have previously identified an important role for extracellular PDI during thrombus formation in vivo. Here, we show that endothelial cells are a critical cellular source of secreted PDI, important for fibrin generation and platelet accumulation in vivo. Functional PDI is rapidly secreted...
متن کاملPlatelet protein disulfide isomerase is required for thrombus formation but not essential for hemostasis in mice. Running title: Role of platelet PDI during thrombus formation
Protein disulfide isomerase (PDI) derived from intravascular cells is required for thrombus formation. However, it remains unclear whether platelet PDI contributes to the process. Using platelet-specific PDI-deficient mice, we demonstrate that PDI-null platelets have defects in aggregation and ATP secretion induced by thrombin, collagen, and ADP. Such defects were rescued by exogenously-added w...
متن کاملTHROMBOSIS AND HEMOSTASIS Endothelium-derived but not platelet-derived protein disulfide isomerase is required for thrombus formation in vivo
Protein disulfide isomerase (PDI) catalyzes the oxidation reduction and isomerization of disulfide bonds. We have previously identified an important role for extracellular PDI during thrombus formation in vivo. Here, we show that endothelial cells are a critical cellular source of secreted PDI, important for fibrin generation and platelet accumulation in vivo. Functional PDI is rapidly secreted...
متن کاملDietary α-linolenic acid inhibits arterial thrombus formation, tissue factor expression, and platelet activation.
OBJECTIVE Plant-derived α-linolenic acid (ALA) may constitute an attractive cardioprotective alternative to fish-derived n-3 fatty acids. However, the effect of dietary ALA on arterial thrombus formation remains unknown. METHODS AND RESULTS Male C57Bl/6 mice were fed a high-ALA or low-ALA diet for 2 weeks. Arterial thrombus formation was delayed in mice fed a high-ALA diet compared with those...
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ژورنال
عنوان ژورنال: Blood
سال: 2018
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2018-99-114418